Selomet 25 | Get Discounted Price from epharma
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Selomet 25 | 1 Strip

Generic: Metoprolol Tartrate

Type: Tablet

Pack Size: 10 Pcs

Selomet is used in the management of:

  • Hypertension
  • Angina pectoris
  • Cardiac arrhythmias (especially supraventricular tachyarrhythmias)
  • Hyperthyroidism (as adjunct therapy)
  • Acute myocardial infarction: Early administration can help reduce infarct size, lower the risk of ventricular fibrillation, and reduce the need for opioid analgesics. Clinical data also shows a reduction in mortality in acute MI patients.

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✅ Description:

Metoprolol is a selective beta1-adrenergic receptor blocker that diminishes the effects of catecholamines (e.g., adrenaline) on the heart. It reduces heart rate, myocardial contractility, and blood pressure, particularly during stress. Unlike non-selective beta-blockers, metoprolol has minimal interference with insulin secretion and less effect on hypoglycemia-induced cardiovascular responses, making it safer for diabetic patients. 

Overdosage Symptoms: Severe hypotension, AV block, bradycardia, cardiogenic shock, coma, bronchospasm, hypoglycemia.
Management: Supportive care, activated charcoal if recent ingestion, use of sympathomimetics (e.g., dopamine, norepinephrine), atropine, glucagon (1–10 mg IV), pacing, and β2 agonists for bronchospasm. Hemodialysis is ineffective.

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✔️ Side Effects
  • Common: Fatigue, dizziness, depression, shortness of breath, headache, bradycardia
  • GI: Nausea, dry mouth, constipation, heartburn
  • Others: Blurred vision, musculoskeletal pain, decreased libido, sleep disturbances, rash, pruritus
✔️ Dosage & Administration

Film-Coated Tablet:

  • Hypertension: 100–400 mg/day, either as a single dose or divided. Initial dose: 100 mg/day, titrated weekly.
  • Angina: 50–100 mg two or three times daily.
  • Arrhythmias: 50 mg 2–3 times daily, up to 300 mg/day if needed.
  • Hyperthyroidism: 50 mg four times daily; adjust as thyroid function normalizes.
  • Myocardial Infarction: 50 mg every 6 hours for 48 hours, then maintenance of 200 mg/day in divided doses.

Extended-Release Tablet:

  • Hypertension: 25–100 mg once daily.
  • Angina: Start with 100 mg/day, adjusted as needed.
  • Heart Failure (NYHA Class II-IV): Start with 12.5–25 mg/day; titrate weekly. Discontinue gradually.

Intravenous (IV) Injection:

  • Arrhythmias: 5 mg IV over 1–2 minutes; repeat after 5 minutes (max 10–15 mg).
  • Surgery: 2–4 mg IV at induction or intraoperatively.
  • Myocardial Infarction: 5 mg IV every 2 minutes (max 15 mg), then 50 mg orally every 6 hours for 48 hours.
✔️ Drug Interactions

Increased effects with catecholamine-depleting drugs (e.g., reserpine, MAO inhibitors).

CYP2D6 inhibitors (fluoxetine, paroxetine, quinidine) may raise metoprolol levels.

Co-administration with digoxin or clonidine increases the risk of bradycardia or rebound hypertension.

✔️ Contraindications
  • AV block
  • Severe bradycardia or sick sinus syndrome
  • Uncontrolled heart failure
  • Cardiogenic shock
  • Severe peripheral arterial disease
  • Hypersensitivity to Metoprolol or other beta-blockers
  • Hypotension or significant heart failure during MI
✔️ Special Advise

Hepatic Impairment: Dose adjustment may be necessary.

Pediatric Use: Not established for children <6 years.

Geriatric Use: Generally well tolerated; no significant dosage adjustments needed.

✔️ Pregnancy & Lactation

Pregnancy Category C: Use only if needed.

Lactation: Small amounts are excreted in breast milk; use with caution in breastfeeding women.

✔️ Precautions & Warnings
  • Bronchospastic Disorders: Use cautiously; beta1-selectivity is beneficial.
  • Surgery: Beta-blocker withdrawal before surgery is controversial; caution is advised.
  • Diabetes: May mask signs of hypoglycemia.
  • Peripheral Vascular Disease: May worsen symptoms.
  • Calcium Channel Blockers: Combined use may intensify bradycardia and AV block.
✔️ Storage:

Store in a cool, dry place, protected from light. Keep out of reach of children.

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Check our pricing section for Selomet 25 | 1 Strip price in Bangladesh. After Submitting Order, You may receive phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

📦Pricing Information, Availability:
Product Availability & Pricing Notice Please note that pricing, availability, and service offerings are subject to change due to: Market fluctuations, Manufacturer or supplier adjustments, Product discontinuation or temporary unavailability, Advertising errors. All orders depend on stock availability and staff resources. If services are provided on a time-and-materials basis, any shared estimates are for planning purposes only.

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